Rimonabant / Acomplia selectively blocks the CB1 receptors that are present in the brain and other peripheral organs important in fat/lipid and glucose metabolism, including muscle, gastrointestinal tract, liver and adipose tissue. Basically, it switches off those brain circuits that are responsible for making people hungry while smoking . Acomplia, along with CB1 receptors, reduces the EC system’s over-activity.
Rimonabant / Acomplia is said to have reduced the overall body fat by 10% in one out of three users. Also, it is reported that those users did not gain back more than a kilo over the next two years if the patients remained on Rimonabant. Rimonabant was recommended for those with a BMI of 30 or greater, who were considered obese, and is most successful when combined with exercise and a proper diet.
Rimonabant is an anorectic antiobesity drug that has been withdrawn from the market due to potentially serious side effects. It was approved for use in Europe and other countries, but never approved in the United States. Rimonabant is an inverse agonist for the cannabinoid receptor CB1.It has also been shown to be a μ-opioid receptor antagonist (possibly the contributing factor in its reported dysphoric qualities).Its main effect is reduction in appetite.
Rimonabant was the first selective CB1 receptor blocker to be approved for use anywhere in the world. In Europe, it was indicated for use in conjunction with diet and exercise for patients with a body mass index (BMI) greater than 30 kg/m², or patients with a BMI greater than 27 kg/m² with associated risk factors, such as type 2 diabetes or dyslipidaemia. In the UK, it was available beginning in July 2006. As of 2008, the drug was available in 56 countries.
The Rimonabant is a very great weight loss powders in nowadays markets ,and its purity is very high ,the contents is for 99% ;especially for smoker and is also for patients with cardiovascular diseases.
Chemical Name: ACOMPLIA;RIMONABANT;RIMONABANT(ACOMPLIA,SR141716);5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidinopyrazole-3-carboxamide
CAS No: 168273-06-1
Appearance: White crystalline powder
Function: mainly in weight loss. pharmaceutical intermediates
Export Markets: Global
As a new diet pills, rimonabant can also be used to quit smoking. Not only lose weight, but also lower blood pressure, cholesterol and blood sugar. Rimonabant was studied to be used complementary to diet and exercise to treat obese or overweight patients who suffer from type 2 diabetes and abnormal levels of fat in the blood.
Rimonabant may also be found to be effective in assisting some smokers to quit smoking. It is a weight loss drug, can significantly reduce weight, reduce waist circumference and reduce risk factors for cardiovascular disease, but also can improve blood lipids and insulin resistance and metabolic syndrome, especially for the presence of clinical obesity or heart disease people at risk. It could also prevent the risk of cardiovascular disease.
Rimonabant may also be found to be effective in assisting some smokers to quit smoking. Sanofi is currently conducting studies to determine the possible value of rimonabant in smoking-cessation therapy. The Studies with Rimonabant and Tobacco Use (STRATUS) program involves more than 6,000 subjects. STRATUS is designed to explore two smoking-related therapies: first, to use rimonabant directly to aid in smoking cessation; second, to help prevent weight gain in former smokers. Initial results apparently suggest rimonabant is effective for both uses.
1) besity,weight loss
2) moking cessation
3) ddiction behaviors
4) hort-term memory
5) lockage of effects
How it works?
Rimonabant works by blocking CB1 receptors and the role, CB1 receptors in mammals are widely distributed, the higher the level of the hypothalamus and the limbic system, which is the most important part of the structure of the two control strengthening and food intake. Excessive intake of food and nicotine may lead to overactivity external stimuli EC system. This will act to increase appetite in the hypothalamus, eat or smoke in the role of the nucleus accumbens increased desire, both of which can lead to increased food intake and tobacco dependence continue. Rimonabant is a cannabinoid receptor (CB1) antagonists, by blocking brain tissue cannabinoid receptors to reduce people’s appetite and cravings. Namely to reduce weight while people quit cigarettes dependence on nicotine, to achieve smoking cessation effect.
|Product Name||Rimonabant||Batch No.||160728|
|Test Items||Specification||Test Results|
|Appearance||Off white crystalline powder||Off white crystalline powder|
|Solubility||Conforms||Freely soluble in methanol|
|T.L.C.||Only one spot||Only one spot|
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